Behavior of solvent-exposed hydrophobic groove in the anti-apoptotic Bcl-XL protein: clues for its ability to bind diverse BH3 ligands from MD simulations.

Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of apoptosis.Its overexpression in many human cancers makes it an important target for anti-cancer drugs.Bcl-XL interacts with the BH3 domain of several pro-apoptotic Bcl-2 partners.This helical bundle protein has a pronounced hydrophobic groove which act

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Model selection criteria for dynamic brain PET studies

Abstract Background Several criteria exist to identify the optimal model for quantification of tracer kinetics.The purpose of this study was to evaluate the correspondence in kinetic model preference identification for brain PET studies among five model selection criteria: Akaike Information Criterion (AIC), AIC unbiased (AICC), model selection cri

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